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eLIGE : Mathematics in Biology, Medicine and Pharmacology

Medication is an object or substance that can be used to fight disease, relieve symptoms, or alter the chemical processes in the body. Drug is a material or alloy of materials intended for use in establishing the diagnosis, preventing, reducing, eliminating, curing ailments or symptoms of bodily or animal diseases, injuries or bodily or spiritual ailments and to twist or beautify the body or parts of the human body including traditional medicine and modern medicine.
Here I will present an interesting project that is different from most other projects. eLige is a healthcare project, especially in the manufacture of drugs by analyzing various DNA samples.
For instance, let’s consider such a matter as the problem of the DNA deciphering. Why should we do this? Here are some spheres where this knowledge can be applied.
Scientists in Belgium, Croatia, France, Russia and Spain gathered ground samples and filtered them to separate out the human DNA samples. A single teaspoon of sand contained the traces of woolly rhinoceroses, mammoths, cave bears and ancient hyenas which made the search for human genes difficult. To remove the genetic “white noise”, the scientists developed a special method — they created some kind of a hook made of contemporary mitochondrial DNA. Because the hook belonged to the human kind, it was “catching” specifically the genes similar in some key properties from all the tangle of the samples. This molecular tool helped to discover the Neanderthal men’s DNA in the places where the archeologists hadn’t found neither the bodies, nor the relics belonged to this kind.
Contemporary mitochondrial DNA is the genetic material of DNA that resides within the mitochondria. Mitochondria are organelles in eukaryotic cells that convert the chemical energy of food in a form that can be used by cells, adenosine triphosphate (ATP). Mitochondrial DNA is only a small part of DNA in a eukaryotic cell; most of the DNA is found in the cell nucleus, and in plants, also in chloroplasts.



Search​ ​of​ ​the​ ​Medications
Drug-design or rationalized creation of medications is a field of research actively developed in the recent years. Discovering of the potential medical compounds which block reproduction of the harmful viruses and bacteria in human organism is one of the problems which can be solved by the Elige.re platform. It is almost impossible to check experimentally, if each molecule is a cure for this or that disease. This is why it is necessary to conduct primary selection in this immense variety of chemical compounds basing on their structures and known properties. There are a lot of ways to achieve this goal: for instance, molecular docking and molecular dynamics.

eLIGE Purpose
The project suggests using the computational capabilities of the sub allocated mining networks for finding new types of medicine, protides, other chemical compounds useful for people and similar economically attractive calculations. Cryptocurrency miners use their immense computational capabilities for calculating unique but completely useless information. Project “Elige.re” will direct these computational capabilities to the benefit not only of the participants of the project but of the humanity as a whole.

How
We will combine the existing systems of grid calculations specializing in searching of the new types of medicine (such as the BOINC project) and chemical compounds with the help of the block chain technology. We will use the search of all the possible variants basing on the computational calculations of the participants of the network – the miners – to find the data we need. Later we will expand the functionality of the platform using neural network to increase the probability of discovering the required data. The processed variations will be stored into the blockchain. The miners will receive rewards in platform’s tokens for processing the data and substantial rewards for solving computational problems.

DIFFERENCE FROM SIMILAR PROJECTS
The main difference from such projects as sonm or golem is that our project suggests not to sell the computational capabilities but to use them for quite specific calculations. Unlike our project, such projects as gridcoin don’t do anything useful, in general, they parasite on the others’ calculations and present those calculations as the proof of work (PoW).

BUSINESS MODEL
After the Elige.re platform will receive suitable data, the discovered solution will be partially or fully locked for a year’s period by the smart contract and offered to the interested pharmacological companies and corporations. The profits gain will be used to buy the platform’s tokens, thus raising the price for the project’s tokens and indirectly paying out dividends to the owners of the Elige.re platform’s tokens. In case if the data discovered by the platform will not be bought during the year, it will become unlocked automatically and available to all the interested parties without any limitations for usage.

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